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Sony
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AZBIO CORP
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Grason Stadler
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Journal: Communications Biology
Article Title: Cross-species validation of a human age-related hearing loss candidate KLHDC7B as essential for mammalian hearing
doi: 10.1038/s42003-025-09349-1
Figure Lengend Snippet: A , B DPOAE longitudinally recorded in Klhdc7b Regn+/+ , Klhdc7b Regn +/Δ and Klhdc7b Regn Δ/Δ mice. A Input-output curves of DPOAE signal vs. primary stimulus intensity at 2 and 12 weeks for 16 kHz. B DPOAE thresholds over time at three frequencies. n = 4–9 mice per group. C DPOAEs recorded in Klhdc7b IMPC+/+ , Klhdc7b IMPC+/- , and Klhdc7b IMPC-/- mice plotted against frequency. The stimul i were presented in 2 kHz intervals at 65/55 dB SPL for the f1 and f2 tones, respectively. For A – C data were analyzed via two-way ANOVA followed by Tukey’s test ( B , 8 kHz) or unpaired t tests ( C ). If data failed normality ( A , B 8 kHz and 16 kHz) testing they were analyzed via Mann–Whitney tests. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 between knockout ( Klhdc7b Regn Δ/Δ , Klhdc7b IMPC-/- ) and wild type ( Klhdc7b Regn+/+ , Klhdc7b IMPC+/+ ) mice. + p < 0.05, ++ p < 0.01, +++ p < 0.001, ++ ++ p < 0.0001 between knockout and heterozygous ( Klhdc7b Regn +/Δ , Klhdc7b IMPC+/- ) mice. Thicker lines indicate means, thin lines individual mice, and shaded areas between dotted lines are 95% confidence intervals.
Article Snippet: Tone stimuli were presented via separate MF1 (
Techniques: MANN-WHITNEY, Knock-Out
Journal: Ear and hearing
Article Title: Automated Adaptive Wideband Acoustic Reflex Threshold Estimation in Normal Hearing Adults
doi: 10.1097/AUD.0000000000001102
Figure Lengend Snippet: Data were obtained in the left ear of the example subject. The ART was elicited by an ipsilateral 1000-Hz activator and recorded at ambient pressure. Each line represents the change in absorbance of the probe across frequency in Hz at a given activator level in dB sound pressure level (SPL). A total of six activator trials was required to establish ART. The first ascending run is represented by dashed lines and the second by solid lines. The test began at 80-dB SPL at which level the criteria for a reflex response were not met. The level was increased 5 dB to 85 dB SPL at which the criteria for a reflex response were not met again, and the level was increased to 90 dB SPL at which the criteria for a reflex were obtained. The level decreased to 80 dB SPL and level was increased in 5-dB steps again until a reflex response was obtained. The automated procedure terminated when a reflex response was obtained at 90 dB SPL on two ascending runs.
Article Snippet: Traditional ARTs were obtained with an 85
Techniques:
Journal: Ear and hearing
Article Title: Automated Adaptive Wideband Acoustic Reflex Threshold Estimation in Normal Hearing Adults
doi: 10.1097/AUD.0000000000001102
Figure Lengend Snippet: Mean acoustic reflex threshold (ART) in dB sound pressure level (SPL) by gender in each condition.
Article Snippet: Traditional ARTs were obtained with an 85
Techniques:
Journal: Ear and hearing
Article Title: Automated Adaptive Wideband Acoustic Reflex Threshold Estimation in Normal Hearing Adults
doi: 10.1097/AUD.0000000000001102
Figure Lengend Snippet: Mean acoustic reflex thresholds (ARTs) (+/- one standard deviation) in dB sound pressure level (SPL) obtained on the clinical tympanometer and wideband (WB) system.
Article Snippet: Traditional ARTs were obtained with an 85
Techniques: Standard Deviation